Diet effects on female reproduction in high growth (hg/hg) mice that are deficient in the Socs-2 gene

Reprod Nutr Dev. Jul-Aug 2004;44(4):303-12. doi: 10.1051/rnd:2004035.

Abstract

The detrimental effect of larger body size on reproductive performance has been well documented in mouse models of overgrowth, such as Growth Hormone (GH) transgenics. This study describes the reproductive performance of the High Growth (HG) mouse model of overgrowth. The HG mouse model exhibits overgrowth due to a partially recessive autosomal mutation that increases growth rate and mature body size. The HG phenotype results from the lack of expression of Socs-2, which negatively regulates GH signaling. C57BL/6J (C57) and congenic C57BL/6J-hg/hg (HG) female mice were fed four diets differing in protein and energy content, starting at 8 weeks of age. A complete reproductive cycle from mating to weaning was evaluated. HG mice were 40% larger than C57 and had a higher feed intake throughout the experiment. Significant genotype x diet interactions were detected for growth, body composition and reproductive traits. HG females showed poor reproductive performance compared to controls as demonstrated by their lower fertility during mating, which was not overcome by changes in the diet. No differences were detected in litter size, but HG animals exhibited a longer gestation length and heavier pup weaning weights compared to controls. Reproductive impairment in HG seems to be the consequence of the lack of Socs-2 independent of the effects of increased body size on reproduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Composition / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Diet*
  • Disease Models, Animal*
  • Female
  • Genotype
  • Growth Hormone / physiology
  • Litter Size
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Obesity / genetics
  • Obesity / physiopathology*
  • Random Allocation
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology*
  • Reproduction / genetics
  • Reproduction / physiology*
  • Suppressor of Cytokine Signaling Proteins
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Weaning

Substances

  • DNA-Binding Proteins
  • Repressor Proteins
  • Socs2 protein, mouse
  • Suppressor of Cytokine Signaling Proteins
  • Trans-Activators
  • Growth Hormone