Recognition-induced transformation of microspheres into vesicles: morphology and size control

Oktay Uzun; Amitav Sanyal; Hiroshi Nakade; Raymond J Thibault; Vincent M Rotello

doi:10.1021/ja047643p

Recognition-induced transformation of microspheres into vesicles: morphology and size control

J Am Chem Soc. 2004 Nov 17;126(45):14773-7. doi: 10.1021/ja047643p.

Authors

Oktay Uzun¹, Amitav Sanyal, Hiroshi Nakade, Raymond J Thibault, Vincent M Rotello

Affiliation

¹ Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

PMID: 15535702
DOI: 10.1021/ja047643p

Abstract

Polystyrene functionalized with diamidopyridine (DAP) recognition units self-assembles in nonpolar media to form thermally reversible micrometer-scale spherical aggregates. The size and the thermal stability of these microspheres can be controlled by the molecular weight of the polymer. The addition of thymine-functionalized polymer to these self-assembled microspheres converted them into vesicular aggregates with a controlled size. The morphology change was reversible: the addition of DAP-functionalized polymer converted the vesicles back to microspheres.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biosensing Techniques
Drug Delivery Systems
Microspheres
Molecular Weight
Polystyrenes / chemistry*
Pyridines / chemistry*
Spectrophotometry, Infrared

Substances

Polystyrenes
Pyridines