Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study

Eur J Clin Nutr. 2005 Mar;59(3):456-8. doi: 10.1038/sj.ejcn.1602081.

Abstract

Objective: To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.

Design: Randomized, double-blind, placebo-controlled, parallel-group trial.

Setting: Pusan Paik Hospital, Pusan, Republic of Korea.

Interventions: A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.

Results: Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).

Conclusions: These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / prevention & control
  • Cholesterol / blood*
  • Cholesterol / metabolism
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Double-Blind Method
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Inositol / analogs & derivatives*
  • Inositol / therapeutic use*
  • Insulin / metabolism
  • Male
  • Middle Aged
  • Risk Factors
  • Soybeans / chemistry*

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • pinitol
  • Inositol
  • Cholesterol