Differential diagnosis of chronic dysimmune demyelinating polyneuropathies with and without anti-MAG antibodies

Muscle Nerve. 2005 Jan;31(1):52-8. doi: 10.1002/mus.20230.


The distinction between chronic demyelinating polyneuropathies associated with IgM paraproteinemia and anti-myelin-associated glycoprotein (MAG) antibodies (MAG-PN) and chronic inflammatory demyelinating polyneuropathies (CIDPs) relies on the anti-MAG antibodies assay. The aim of the study was to identify clinical and electrophysiological features suggesting a diagnosis of MAG-PN. Fourteen patients with MAG-PN and 35 with CIDP were included, and a discriminant analysis was performed to identify the clinical and electrophysiological features suggestive of MAG-PN. Pure sensory clinical phenotype, low median and ulnar terminal latency index, and absence of M responses in the lower limbs were significantly associated with the diagnosis of MAG-PN, and indicate a moderate to large increase in probability of this diagnosis in patients with chronic dysimmune demyelinating polyneuropathies.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / blood*
  • Biomarkers
  • Diabetes Complications
  • Diagnosis, Differential
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myelin-Associated Glycoprotein / immunology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / complications
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology*
  • Predictive Value of Tests
  • Prospective Studies


  • Autoantibodies
  • Biomarkers
  • Myelin-Associated Glycoprotein