A microbial TRP-like polycystic-kidney-disease-related ion channel gene

Biochem J. 2005 Apr 1;387(Pt 1):211-9. doi: 10.1042/BJ20041710.

Abstract

Ion channel genes have been discovered in many microbial organisms. We have investigated a microbial TRP (transient receptor potential) ion channel gene which has most similarity to polycystic-kidney-disease-related ion channel genes. We have shown that this gene (pkd2) is essential for cellular viability, and is involved in cell growth and cell wall synthesis. Expression of this gene increases following damage to the cell wall. This fission yeast pkd2 gene, orthologues of which are found in all eukaryotic cells, appears to be a key signalling component in the regulation of cell shape and cell wall synthesis in yeast through an interaction with a Rho1-GTPase. A model for the mode of action of this Schizosaccharomyces pombe protein in a Ca2+ signalling pathway is hypothesized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence / genetics
  • Calcium Signaling / genetics
  • Cyclin-Dependent Kinase 8
  • Cyclin-Dependent Kinases / genetics*
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • Polycystic Kidney Diseases / genetics*
  • Protein Kinases / genetics
  • Schizosaccharomyces pombe Proteins
  • Sequence Homology, Amino Acid

Substances

  • Schizosaccharomyces pombe Proteins
  • Protein Kinases
  • protein kinase D2
  • Cyclin-Dependent Kinase 8
  • Cyclin-Dependent Kinases
  • srb10 protein, S pombe