HDAC4: a corepressor controlling bone development

Cell. 2004 Nov 12;119(4):448-9. doi: 10.1016/j.cell.2004.10.023.

Abstract

RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bone Development
  • Chondrocytes / physiology*
  • Core Binding Factor Alpha 1 Subunit
  • Histone Deacetylases / genetics
  • Histone Deacetylases / physiology*
  • Hypertrophy
  • Mice
  • Mutation
  • Neoplasm Proteins / metabolism
  • Neoplasm Proteins / physiology
  • Osteogenesis
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology
  • Transfection

Substances

  • Core Binding Factor Alpha 1 Subunit
  • Neoplasm Proteins
  • Repressor Proteins
  • Transcription Factors
  • HDAC4 protein, human
  • Histone Deacetylases