Hereditary palmoplantar (epidermolytic) keratoderma: illustration through a familial report

Skinmed. 2004 Nov-Dec;3(6):323-30; quiz 331-2. doi: 10.1111/j.1540-9740.2004.03243.x.


Hereditary palmoplantar keratoderma, a well-known clinical entity, is illustrated through a familial report of an unmarried young man who is the product of a consanguineous marriage (paternal and maternal grandmothers were sisters). The lesions were characterized by immense yellow waxy thickening of the skin surrounded by erythematous border (halo) and fissures/cracks associated with extensive scaling of the palms and soles. The lesions were bilateral and symmetrical. These features were supported by orthokeratotic hyperkeratosis hypergranulosis and acanthosis in hematoxylin-eosin stained tissue sections prepared from the soles. Mycelia/spores could not be identified on Periodic acid-Schiff (PAS) reaction. An autosomal dominant trait was revealed through family pedigree. An abridged update to recap the current status is highlighted.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Administration, Topical
  • Adult
  • Age Distribution
  • Aged
  • Biopsy, Needle
  • Dermatologic Agents / therapeutic use
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Immunohistochemistry
  • Incidence
  • India / epidemiology
  • Keratoderma, Palmoplantar / drug therapy
  • Keratoderma, Palmoplantar / epidemiology
  • Keratoderma, Palmoplantar / genetics*
  • Keratoderma, Palmoplantar / pathology*
  • Male
  • Middle Aged
  • Pedigree
  • Prognosis
  • Risk Assessment
  • Severity of Illness Index
  • Sex Distribution
  • Skin Diseases, Genetic / diagnosis*
  • Skin Diseases, Genetic / drug therapy
  • Skin Diseases, Genetic / epidemiology


  • Dermatologic Agents