Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period

J Comput Assist Tomogr. 2004 Nov-Dec;28(6):790-5. doi: 10.1097/00004728-200411000-00010.


Objective: To evaluate thin-section computed tomography findings of patients with severe acute respiratory syndrome (SARS) in the convalescent period and to correlate the results with clinical parameters and lung function tests.

Methods: Ninety-nine severe acute respiratory syndrome patients with persistent changes on follow-up chest radiography were included. One hundred seventy computed tomography examinations at baseline (n=70), 3 months (n=56), and 6 months (n=44) were retrospectively evaluated to determine the extent of ground-glass opacification, reticulation, and total parenchymal involvement. Patients' demographic information, clinical information during treatment, and results of lung function tests at 3 and 6 months were correlated with computed tomography findings.

Results: A significant serial improvement in the extent of overall ground-glass opacification, overall reticulation, and total parenchymal involvement was observed (P <0.01). Advanced age, previous intensive care unit admission, mechanical ventilation, alternative treatment, higher peak lactate dehydrogenase, and peak radiographic involvement during treatment showed a positive correlation with overall reticulation and total parenchymal involvement at 6 months. There was a significant negative correlation between overall reticulation and total parenchymal involvement with diffusion capacity adjusted for hemoglobin at 3 and 6 months (P <0.01).

Conclusion: Lung changes on thin-section computed tomography of severe acute respiratory syndrome patients improved with time during the convalescent period and showed a significant correlation with advanced age, parameters indicating severe illness, and diffusion capacity adjusted for hemoglobin on follow-up.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Convalescence
  • Female
  • Follow-Up Studies
  • Hemoglobins / analysis
  • Humans
  • Intensive Care Units
  • L-Lactate Dehydrogenase / blood
  • Lung / diagnostic imaging
  • Lung / physiopathology
  • Male
  • Middle Aged
  • Patient Admission
  • Pulmonary Diffusing Capacity / physiology
  • Respiration, Artificial
  • Respiratory Function Tests
  • Retrospective Studies
  • Severe Acute Respiratory Syndrome / blood
  • Severe Acute Respiratory Syndrome / diagnostic imaging*
  • Severe Acute Respiratory Syndrome / physiopathology
  • Tomography, X-Ray Computed / methods*


  • Hemoglobins
  • L-Lactate Dehydrogenase