Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus

Clin Diagn Lab Immunol. 2004 Nov;11(6):1194-7. doi: 10.1128/CDLI.11.6.1194-1197.2004.

Abstract

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Cell Surface / genetics*
  • Staphylococcal Infections / genetics*
  • Staphylococcus aureus*
  • Toll-Like Receptor 2
  • Toll-Like Receptors

Substances

  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • TLR2 protein, human
  • Toll-Like Receptor 2
  • Toll-Like Receptors