Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection

Parasite Immunol. Jun-Jul 2004;26(6-7):265-72. doi: 10.1111/j.0141-9838.2004.00705.x.

Abstract

A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / blood*
  • Antigens, Protozoan / immunology*
  • Burkina Faso
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Infant
  • Longitudinal Studies
  • Malaria, Falciparum / immunology*
  • Malaria, Falciparum / prevention & control
  • Male
  • Oligopeptides / immunology*
  • Plasmodium falciparum / immunology*
  • Protozoan Proteins / immunology*

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Immunoglobulin G
  • Oligopeptides
  • Protozoan Proteins
  • QF116 antigen, Plasmodium falciparum
  • merozoite surface protein 3, Plasmodium
  • glutamate-rich protein, Plasmodium