Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction

Am J Cardiol. 2004 Nov 15;94(10):1306-10. doi: 10.1016/j.amjcard.2004.07.121.

Abstract

This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q(10) supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anticholesteremic Agents / adverse effects
  • Anticholesteremic Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Atorvastatin
  • Coenzymes
  • Echocardiography, Doppler
  • Female
  • Heptanoic Acids / adverse effects
  • Heptanoic Acids / pharmacology*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Male
  • Middle Aged
  • Pyrroles / adverse effects
  • Pyrroles / pharmacology*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / pharmacology*
  • Ventricular Function, Left / drug effects*

Substances

  • Anticholesteremic Agents
  • Antioxidants
  • Coenzymes
  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Ubiquinone
  • Atorvastatin
  • coenzyme Q10