Abstract
On average, metoprolol plasma concentration is doubled after an amiodarone loading dose (1.2 g/day over a period of 6 days). However, the individual amount of this drug interaction depends on the CYP2D6 genotype.
MeSH terms
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Aged
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Alleles
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Amiodarone / pharmacology*
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Anti-Arrhythmia Agents / pharmacokinetics
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Anti-Arrhythmia Agents / pharmacology*
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Atrial Fibrillation / blood
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Atrial Fibrillation / drug therapy*
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Atrial Fibrillation / genetics
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Cytochrome P-450 CYP2D6 / genetics
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Drug Interactions
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Drug Therapy, Combination
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Female
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Genotype
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Humans
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Male
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Metoprolol / pharmacokinetics*
Substances
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Anti-Arrhythmia Agents
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Cytochrome P-450 CYP2D6
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Metoprolol
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Amiodarone