Effect of amiodarone on the plasma levels of metoprolol

Am J Cardiol. 2004 Nov 15;94(10):1319-21. doi: 10.1016/j.amjcard.2004.07.125.

Abstract

On average, metoprolol plasma concentration is doubled after an amiodarone loading dose (1.2 g/day over a period of 6 days). However, the individual amount of this drug interaction depends on the CYP2D6 genotype.

MeSH terms

  • Aged
  • Alleles
  • Amiodarone / pharmacology*
  • Anti-Arrhythmia Agents / pharmacokinetics
  • Anti-Arrhythmia Agents / pharmacology*
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / drug therapy*
  • Atrial Fibrillation / genetics
  • Cytochrome P-450 CYP2D6 / genetics
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Genotype
  • Humans
  • Male
  • Metoprolol / pharmacokinetics*

Substances

  • Anti-Arrhythmia Agents
  • Cytochrome P-450 CYP2D6
  • Metoprolol
  • Amiodarone