Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

Biochem Biophys Res Commun. 2004 Dec 17;325(3):852-6. doi: 10.1016/j.bbrc.2004.10.107.


Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca(2+)-induced Ca(2+) release in the heart.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Cardiomyopathy, Dilated / metabolism*
  • Cardiomyopathy, Hypertrophic / metabolism*
  • Caveolin 3
  • Caveolins / metabolism*
  • Disease Models, Animal
  • Down-Regulation
  • Gene Expression Regulation, Developmental
  • Heart Ventricles / embryology*
  • Heart Ventricles / metabolism*
  • Membrane Proteins / metabolism*
  • Mice
  • Mice, Inbred ICR
  • Mice, Transgenic / metabolism
  • Myocytes, Cardiac / metabolism*


  • Biomarkers
  • Cav3 protein, mouse
  • Caveolin 3
  • Caveolins
  • Membrane Proteins
  • junctophilin