The expanding role of PSD-95: a new link to addiction

Trends Neurosci. 2004 Dec;27(12):699-700. doi: 10.1016/j.tins.2004.09.002.

Abstract

One feature of addiction is the enhanced locomotor response known as behavioral sensitization that occurs with prolonged exposure to psychostimulants. In a recent study, Yao et al. have analyzed four distinct animal models that share this common phenotype. Evaluation of gene expression in the striatum reveals that postsynaptic density (PSD)-95, a synaptic scaffolding protein, is downregulated in each model, suggesting an essential role for this protein in addiction.

MeSH terms

  • Animals
  • Behavior, Addictive / metabolism*
  • Disks Large Homolog 4 Protein
  • Gene Expression Regulation
  • Guanylate Kinases
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Motor Activity / physiology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neuronal Plasticity / physiology
  • Oligonucleotide Array Sequence Analysis
  • Synapses / metabolism

Substances

  • Disks Large Homolog 4 Protein
  • Dlg4 protein, mouse
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • postsynaptic density proteins
  • Guanylate Kinases