A contemporary understanding of progesterone receptor function

Mech Ageing Dev. Oct-Nov 2004;125(10-11):669-78. doi: 10.1016/j.mad.2004.04.007.

Abstract

Following the discovery of coactivators for nuclear receptors and the identification of a significant number of progesterone receptor (PR) target genes, our understanding of PR action has extended from its normally recognized functions to a wide variety of seemingly unlinked biological processes. Recent advances in defining the action of PR coactivators has revealed important mechanisms involving multiple layers of regulation in PR-mediated transcription. In this review, we will discuss the current understanding of PR physiology and the molecular basis of coactivator function in PR signaling events.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology*
  • Humans
  • Progesterone / physiology*
  • Receptors, Progesterone / physiology*
  • Signal Transduction / physiology*

Substances

  • Receptors, Progesterone
  • Progesterone