Elevated body temperature enhances the laryngeal chemoreflex in decerebrate piglets

J Appl Physiol (1985). 2005 Mar;98(3):780-6. doi: 10.1152/japplphysiol.00906.2004. Epub 2004 Nov 12.

Abstract

Hyperthermia and reflex apnea may both contribute to sudden infant death syndrome (SIDS). Therefore, we investigated the effect of increased body temperature on the inhibition of breathing produced by water injected into the larynx, which elicits the laryngeal chemoreflex (LCR). We studied decerebrated, vagotomized, neonatal piglets aged 3-15 days. Blood pressure, end-tidal CO(2), body temperature, and phrenic nerve activity were recorded. To elicit the LCR, we infused 0.1 ml of distilled water through a polyethylene tube passed through the nose and positioned just rostral to the larynx. Three to five LCR trials were performed with the piglet at normal body temperature. The animal's core body temperature was raised by approximately 2.5 degrees C, and three to five LCR trials were performed before the animal was cooled, and three to five LCR trials were repeated. The respiratory inhibition associated with the LCR was substantially prolonged when body temperature was elevated. Thus elevated body temperature may contribute to the pathogenesis of SIDS by increasing the inhibitory effects of the LCR.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Body Temperature*
  • Chemoreceptor Cells / drug effects
  • Chemoreceptor Cells / physiopathology*
  • Decerebrate State / complications
  • Decerebrate State / physiopathology*
  • Fever / complications
  • Fever / physiopathology*
  • Laryngeal Nerves / drug effects
  • Laryngeal Nerves / physiopathology*
  • Larynx / drug effects
  • Larynx / physiopathology*
  • Reflex*
  • Swine
  • Water / adverse effects

Substances

  • Water