Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila

Nat Neurosci. 2004 Dec;7(12):1293-5. doi: 10.1038/nn1346. Epub 2004 Nov 7.

Abstract

Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons. Here we examined their mutant and overexpression phenotypes in Drosophila melanogaster. We found that mutants neurons had normal axon and dendrite morphology and remodeled axons correctly in metamorphosis, and that overexpression did not affect axon or dendrite specification. Baz/Par-6/aPKC are therefore not essential for axon specification in Drosophila.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / metabolism*
  • Dendrites / metabolism*
  • Drosophila Proteins / biosynthesis
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Metamorphosis, Biological / genetics
  • Mutation
  • Protein Kinase C / biosynthesis
  • Protein Kinase C / genetics
  • Protein Kinase C / physiology*
  • Proteins / genetics
  • Proteins / metabolism
  • Proteins / physiology*

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • baz protein, Drosophila
  • PKC-3 protein
  • Protein Kinase C