Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?

Mediators Inflamm. 2004 Aug;13(4):275-83. doi: 10.1080/09629350400003100.


Aims: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value.

Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels.

Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Chemokine CCL2 / blood
  • Cohort Studies
  • Cytokines / blood*
  • Female
  • Humans
  • Interleukins / blood
  • Male
  • Middle Aged
  • Monocytes / metabolism
  • Neopterin / blood
  • Predictive Value of Tests
  • Prognosis
  • Receptors, Tumor Necrosis Factor, Type I / blood
  • Vasculitis / immunology*


  • Antibodies, Antineutrophil Cytoplasmic
  • CCL2 protein, human
  • Chemokine CCL2
  • Cytokines
  • Interleukins
  • Receptors, Tumor Necrosis Factor, Type I
  • Neopterin