The genomes of recombinant inbred lines

Genetics. 2005 Feb;169(2):1133-46. doi: 10.1534/genetics.104.035212. Epub 2004 Nov 15.


Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.

MeSH terms

  • Alleles
  • Animals
  • Chromosome Breakage
  • Chromosome Mapping
  • Chromosomes
  • Crossing Over, Genetic
  • Female
  • Genetic Linkage
  • Genome*
  • Inbreeding
  • Male
  • Meiosis
  • Mice
  • Mice, Inbred Strains / genetics*
  • Recombination, Genetic*
  • X Chromosome