The protein-conducting channel SecYEG

Biochim Biophys Acta. 2004 Nov 11;1694(1-3):81-95. doi: 10.1016/j.bbamcr.2004.02.009.


In bacteria, the translocase mediates the translocation of proteins into or across the cytosolic membrane. It consists of a membrane embedded protein-conducting channel and a peripherally associated motor domain, the ATPase SecA. The channel is formed by SecYEG, a multimeric protein complex that assembles into oligomeric forms. The structure and subunit composition of this protein-conducting channel is evolutionary conserved and a similar system is found in the endoplasmic reticulum of eukaryotes and the cytoplasmic membrane of archaea. The ribosome and other membrane proteins can associate with the protein-conducting channel complex and affect its activity or functionality.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Escherichia coli Proteins / metabolism
  • Escherichia coli Proteins / physiology*
  • Membrane Proteins / chemistry
  • Membrane Proteins / physiology*
  • Membrane Transport Proteins / physiology*
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Subunits / chemistry
  • Protein Subunits / physiology
  • SEC Translocation Channels


  • Escherichia coli Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Protein Subunits
  • SEC Translocation Channels
  • SecE protein, E coli
  • SecG protein, E coli
  • SecY protein, E coli