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, 14 (24), 5975-8

Isosteric N-arylpiperazine Replacements in a Series of Dihydropyridine NPY1 Receptor Antagonists

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Isosteric N-arylpiperazine Replacements in a Series of Dihydropyridine NPY1 Receptor Antagonists

Guanglin Luo et al. Bioorg Med Chem Lett.

Abstract

4-Amino-N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY1 receptor antagonists. These were prepared by a ZnCl2-mediated reductive amination reaction between elaborated primary amines, 2 or 5, and 4-arylpiperidones.

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