The molecular physiology of tight junction pores

Physiology (Bethesda). 2004 Dec;19:331-8. doi: 10.1152/physiol.00027.2004.


Tight junctions form selective barriers that regulate paracellular transport across epithelia. A large family of tetraspanning cell-cell adhesion proteins called claudins create the barrier and regulate electrical resistance, size, and ionic charge selectivity. Study of inherited human claudin diseases and the outcome of the genetic manupulation of claudins in mice, Drosophila, and Caenorhabditis elegans are furthering our understanding of paracellular physiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Epithelial Cells / physiology*
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Tight Junctions / physiology*


  • Membrane Proteins