Regulation of ion transport by the NHERF family of PDZ proteins

Physiology (Bethesda). 2004 Dec;19:362-9. doi: 10.1152/physiol.00020.2004.


NHERFs are the best-studied apical PDZ proteins that are highly expressed in epithelial cells. Molecular and cellular studies over the past decade show that NHERFs regulate the targeting or trafficking of ion transporters and other membrane proteins and transduce physiological and pathophysiological signals that regulate ion homeostasis in mammals.

Publication types

  • Review

MeSH terms

  • Animals
  • Homeostasis / physiology
  • Humans
  • Ion Transport / physiology*
  • Phosphoproteins / chemistry*
  • Phosphoproteins / physiology*
  • Protein Structure, Tertiary
  • Sodium-Hydrogen Exchangers


  • Phosphoproteins
  • Sodium-Hydrogen Exchangers
  • sodium-hydrogen exchanger regulatory factor