Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants

Am J Obstet Gynecol. 2004 Nov;191(5):1649-54. doi: 10.1016/j.ajog.2004.04.014.


Objectives: In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study.

Study design: Eighteen premature infants with CLD were enrolled. Cord blood plasma levels of cytokines of these infants and 12 control infants without CLD were measured including interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, soluble TNF receptor-I, and soluble IL-6 receptor using a cytometric bead array and an enzyme-linked immunosorbent assay.

Results: The cord blood IL-6, IL-8, and sTNFR-I levels were significantly elevated in CLD infants compared with those in control (P < .05). IL-1beta, IL-2, IL-4, IL-10, and IFN-gamma were undetectable in both groups. CLD infants with maternal chorioamnionitis had higher IL-6 than those without chorioamnionitis (P < .01). In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P < .05).

Conclusion: Elevated inflammatory cytokines in the cord blood are associated with the progression to CLD.

Publication types

  • Evaluation Study

MeSH terms

  • Case-Control Studies
  • Chronic Disease
  • Cytokines / blood*
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fetal Blood / metabolism*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Lung Diseases / blood
  • Lung Diseases / diagnosis
  • Male
  • Predictive Value of Tests
  • Receptors, Tumor Necrosis Factor, Type I / blood
  • Respiratory Distress Syndrome, Newborn / blood*
  • Respiratory Distress Syndrome, Newborn / diagnosis


  • Cytokines
  • Interleukin-6
  • Interleukin-8
  • Receptors, Tumor Necrosis Factor, Type I