Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease

Int J Mol Med. 2004 Dec;14(6):1061-4.


The receptor for advanced glycation end products (RAGE) is thought to play a critical role in diabetic atherosclerosis. Accordingly, a functional -374T/A polymorphism in RAGE gene promoter has been associated with macrovascular complications in type 1 diabetic patients. However, the extent to which this common variant influences the risk of coronary artery disease (CAD) in the general population remains to be determined. We genotyped the -374T/A RAGE polymorphism in 259 non-diabetic individuals, of whom 175 had angiographically documented coronary artery disease (CAD patients) and 84 had normal coronary angiography (CAD-free control subjects). Homozygosity for the -374A allele was found in 9.7% of the CAD patients versus 22.6% of the CAD-free subjects (p=0.005). By means of a multiple logistic regression analysis, the AA genotype of the -374T/A polymorphism was shown to be independently associated with a reduced risk of CAD (adjusted odds ratio 0.33, 95% CI 0.15 to 0.73; p=0.006). Our observations suggest that the -374T/A polymorphism of the RAGE gene may reduce susceptibility to CAD, thus exerting a protective effect on coronary risk. Future pathophysiological studies may be worthwhile to clarify the mechanisms behind this association.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / genetics*
  • Alleles
  • Coronary Angiography
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / pathology
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / genetics*
  • Thymidine / genetics*


  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic
  • Adenosine
  • Thymidine