Stromal Fibroblasts in Cancer Initiation and Progression

Nature. 2004 Nov 18;432(7015):332-7. doi: 10.1038/nature03096.

Abstract

It is widely accepted that the development of carcinoma--the most common form of human cancer--is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Disease Progression
  • Fibroblasts / metabolism
  • Fibroblasts / pathology*
  • Humans
  • Neoplasms, Glandular and Epithelial / metabolism
  • Neoplasms, Glandular and Epithelial / pathology*
  • Neoplasms, Glandular and Epithelial / therapy
  • Signal Transduction
  • Stromal Cells / metabolism
  • Stromal Cells / pathology*