Aneuploidy and cancer

Nature. 2004 Nov 18;432(7015):338-41. doi: 10.1038/nature03099.


In contrast to normal cells, aneuploidy--alterations in the number of chromosomes--is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.

Publication types

  • Review

MeSH terms

  • Aneuploidy*
  • Animals
  • Chromosomal Instability / genetics*
  • Chromosome Segregation
  • Humans
  • Mitosis / genetics
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / pathology*
  • Prognosis