Nucleocapsid protein as early diagnostic marker for SARS

Emerg Infect Dis. 2004 Nov;10(11):1947-9. doi: 10.3201/eid1011.040516.


Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood
  • Biomarkers
  • Humans
  • Nucleocapsid Proteins / blood*
  • SARS Virus / isolation & purification*
  • Severe Acute Respiratory Syndrome / diagnosis*
  • Time Factors


  • Antibodies, Viral
  • Biomarkers
  • Nucleocapsid Proteins