Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong

Pak-Leung Ho; Kin Hung Chow; Gannon C Mak; Kenneth W Tsang; Yu Lung Lau; Alex Y Ho; Eileen L Lai; Susan S Chiu

doi:10.3201/eid1011.040055

Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong

Emerg Infect Dis. 2004 Nov;10(11):1960-2. doi: 10.3201/eid1011.040055.

Authors

Pak-Leung Ho¹, Kin Hung Chow, Gannon C Mak, Kenneth W Tsang, Yu Lung Lau, Alex Y Ho, Eileen L Lai, Susan S Chiu

Affiliation

¹ Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong Special Administrative Region, China. plho@hkucc.hku.hk

Abstract

Among 563 strains of Haemophilus influenzae from young children in Hong Kong, 5 (0.9%) had decreased susceptibility to quinolones. The five strains had a Ser-84-Lys or Asp-88-Asn substitution in GyrA. Pulsed-field gel electrophoresis showed that the isolates are genetically diverse.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Carrier State
Child
Child, Preschool
Drug Resistance, Bacterial*
Haemophilus influenzae / drug effects*
Hong Kong
Humans
Infant
Levofloxacin*
Nalidixic Acid / pharmacology
Nasopharynx / microbiology
Ofloxacin / pharmacology*

Substances

Anti-Bacterial Agents
Nalidixic Acid
Levofloxacin
Ofloxacin