The life and times of ivermectin - a success story

Nat Rev Microbiol. 2004 Dec;2(12):984-9. doi: 10.1038/nrmicro1048.

Abstract

Since its introduction more than 20 years ago, ivermectin has proved to be one of the most successful therapeutic drugs in veterinary medicine, as well as the basis of one of the most successful public-health programmes of the past century. The drug arose from a unique international collaboration between the public and private sectors. The development process also incorporated the world's first and largest drug-donation programme and involved a unique association between governments, non-governmental organizations and industry. The drug is now being used, free of charge, in two global disease-elimination programmes that are benefiting millions of the world's poorest people.

Publication types

  • Review

MeSH terms

  • Africa / epidemiology
  • Americas / epidemiology
  • Animals
  • Anthelmintics* / chemistry
  • Anthelmintics* / economics
  • Anthelmintics* / metabolism
  • Anthelmintics* / therapeutic use
  • Community Networks
  • Costs and Cost Analysis
  • Elephantiasis, Filarial / drug therapy
  • Humans
  • Ivermectin* / chemistry
  • Ivermectin* / economics
  • Ivermectin* / metabolism
  • Ivermectin* / therapeutic use
  • Life Cycle Stages
  • Onchocerca volvulus / physiology
  • Onchocerciasis / drug therapy*
  • Onchocerciasis / epidemiology
  • Onchocerciasis / veterinary
  • Streptomyces / metabolism

Substances

  • Anthelmintics
  • Ivermectin