Expression levels of protein kinase C-alpha in non-small-cell lung cancer

Clin Lung Cancer. 2004 Nov;6(3):184-9. doi: 10.3816/clc.2004.n.032.


Current treatments of non-small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC)-alpha, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-alpha in NSCLC to better understand the distribution of PKC-alpha in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-alpha protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-a-associated gene expression profiles in NSCLC. We found that PKC-alpha is highly expressed in < or = 20% of patients with NSCLC. We also found that PKC-alpha was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Gene Expression Profiling*
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Oligonucleotide Array Sequence Analysis
  • Protein Kinase C / genetics*
  • Protein Kinase C-alpha
  • RNA, Messenger / metabolism


  • RNA, Messenger
  • PRKCA protein, human
  • Protein Kinase C
  • Protein Kinase C-alpha