Molecular physiology and modulation of somatodendritic A-type potassium channels

Mol Cell Neurosci. 2004 Dec;27(4):343-69. doi: 10.1016/j.mcn.2004.06.011.


The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical component of the ensemble of voltage-gated ionic currents that determine somatodendritic signal integration. The underlying K+ channel belongs to the Shal subfamily of voltage-gated K+ channels. Most Shal channels across the animal kingdom share a high degree of structural conservation, operate in the subthreshold range of membrane potentials, and exhibit relatively fast inactivation and recovery from inactivation. Mammalian Shal K+ channels (Kv4) undergo preferential closed-state inactivation with features that are generally inconsistent with the classical mechanisms of inactivation typical of Shaker K+ channels. Here, we review (1) the physiological and genetic properties of ISA, 2 the molecular mechanisms of Kv4 inactivation and its remodeling by a family of soluble calcium-binding proteins (KChIPs) and a membrane-bound dipeptidase-like protein (DPPX), and (3) the modulation of Kv4 channels by protein phosphorylation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium-Binding Proteins
  • Dendrites / physiology*
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • Evolution, Molecular
  • Humans
  • Kv Channel-Interacting Proteins
  • Membrane Potentials / genetics
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Phosphorylation
  • Phylogeny
  • Potassium Channels / genetics
  • Potassium Channels / metabolism
  • Potassium Channels, Voltage-Gated / genetics
  • Potassium Channels, Voltage-Gated / metabolism*
  • Sequence Homology, Amino Acid
  • Shal Potassium Channels


  • Calcium-Binding Proteins
  • KCNIP1 protein, human
  • Kv Channel-Interacting Proteins
  • Nerve Tissue Proteins
  • Potassium Channels
  • Potassium Channels, Voltage-Gated
  • Shal Potassium Channels
  • DPP6 protein, rat
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases