A fibrinogen-binding protein of Staphylococcus lugdunensis

FEMS Microbiol Lett. 2004 Dec 1;241(1):87-93. doi: 10.1016/j.femsle.2004.10.008.

Abstract

A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins / analysis*
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism
  • Fibrinogen / metabolism*
  • Molecular Sequence Data
  • Staphylococcus / chemistry*

Substances

  • Carrier Proteins
  • Fibrinogen