IL-19 induced Th2 cytokines and was up-regulated in asthma patients

J Immunol. 2004 Dec 1;173(11):6712-8. doi: 10.4049/jimmunol.173.11.6712.


IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene-7 (IL-24), and AK155 (IL-26). IL-10 has been shown to inhibit allergen-induced airway hyperreactivity and inflammation. To determine whether IL-19 was also associated with asthma, we used ELISA to analyze the serum level of IL-19 in patients with asthma and found that their serum IL-19 levels were twice those of healthy controls. Patients with a high level of IL-19 also had high levels of IL-4 and IL-13. In a dust mite-induced murine model of asthma, we found that IL-19 level in asthmatic BALB/cJ mice was also twice that of healthy control mice. IL-19 transcript was also induced in the lungs of asthmatic mice. Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. However, IL-19 up-regulated IL-13 in asthmatic mice. In vitro, IL-19 induced IL-4, IL-5, IL-10, and IL-13 production by activated T cells. Activation of T cells was required for induction of IL-13 because IL-19 did not induce IL-13 production on nonstimulated T cells. Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Asthma / immunology*
  • Asthma / metabolism
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Child
  • Child, Preschool
  • Cytokines / biosynthesis*
  • Disease Models, Animal
  • Female
  • Humans
  • Immunoglobulin E / biosynthesis
  • Interleukin-10 / biosynthesis*
  • Interleukin-10 / blood
  • Interleukin-10 / genetics
  • Interleukin-10 / physiology*
  • Interleukin-13 / biosynthesis
  • Interleukin-13 / blood
  • Interleukin-13 / genetics
  • Interleukin-4 / biosynthesis
  • Interleukin-4 / blood
  • Interleukin-5 / biosynthesis
  • Interleukins
  • Jurkat Cells
  • Lymphocyte Activation / immunology
  • Mice
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Th2 Cells / immunology*
  • Th2 Cells / metabolism*
  • Transcription, Genetic
  • Up-Regulation / immunology*


  • Cytokines
  • IL19 protein, human
  • Il19 protein, mouse
  • Interleukin-13
  • Interleukin-5
  • Interleukins
  • Interleukin-10
  • Interleukin-4
  • Immunoglobulin E