Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase

Sirichai Adisakwattana; Nattaya Ngamrojanavanich; Kanyarat Kalampakorn; Wilaiwon Tiravanit; Sophon Roengsumran; Sirintorn Yibchok-Anun

doi:10.1080/14756360409162443

Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase

J Enzyme Inhib Med Chem. 2004 Aug;19(4):313-6. doi: 10.1080/14756360409162443.

Authors

Sirichai Adisakwattana¹, Nattaya Ngamrojanavanich, Kanyarat Kalampakorn, Wilaiwon Tiravanit, Sophon Roengsumran, Sirintorn Yibchok-Anun

Affiliation

¹ Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.

PMID: 15558946
DOI: 10.1080/14756360409162443

Abstract

Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 microM +/- 0.24 microM, compared with the IC50 value of voglibose (IC50 = 23.4 +/- 0.30 microM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a Ki value in the range of 1.31-1.56 x 10(-5)M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthocyanins / chemical synthesis
Anthocyanins / chemistry
Anthocyanins / pharmacology*
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology*
Glycoside Hydrolase Inhibitors*
Inositol / analogs & derivatives*
Inositol / pharmacology
Kinetics
Molecular Structure
Yeasts / enzymology
alpha-Glucosidases / chemistry

Substances

Anthocyanins
Enzyme Inhibitors
Glycoside Hydrolase Inhibitors
Inositol
alpha-Glucosidases
cyanidin 3-rutinoside
voglibose