Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases

Cytokine Growth Factor Rev. 2004 Dec;15(6):411-7. doi: 10.1016/j.cytogfr.2004.09.003.


The purpose of this review is to outline the main role of nerve growth factor (NGF) in the visual system and particularly in the ocular surface in physiological and pathological conditions. The present review of experimental and clinical studies will highlight old and recent strategies for treating ocular surface and tear disorders with NGF.

Publication types

  • Review

MeSH terms

  • Eye Diseases* / immunology
  • Eye Diseases* / pathology
  • Eye Diseases* / physiopathology
  • Humans
  • Hypersensitivity / pathology
  • Hypersensitivity / physiopathology*
  • Nerve Growth Factor / metabolism*
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / physiopathology*
  • Ocular Physiological Phenomena
  • Receptor, Nerve Growth Factor
  • Receptor, trkA / metabolism
  • Receptors, Nerve Growth Factor / metabolism


  • Receptor, Nerve Growth Factor
  • Receptors, Nerve Growth Factor
  • Nerve Growth Factor
  • Receptor, trkA