The influence of androgen deprivation therapy on metabolism in patients with prostate cancer

J Clin Endocrinol Metab. 2005 Feb;90(2):657-60. doi: 10.1210/jc.2004-1611. Epub 2004 Nov 23.


The effects of androgen deprivation therapy (ADT) include not only suppression of tumor growth, but also adverse effects on various bodily functions. The aim of this study was to determine the metabolic effects of ADT in patients with nonmetastatic prostate cancer. Forty-nine men with prostate cancer were treated with ADT before beginning radical therapy for 6 months. Body weight, peripheral red blood cell counts, hemoglobin, hematocrit, fasting blood sugar, serum total cholesterol, blood urea nitrogen, uric acid, compensated calcium, inorganic phosphorus, bone-specific alkaline phosphatase, urinary deoxypyridinoline, and radial bone density determined using dual energy x-ray absorptiometry were examined before and 6 months after ADT treatment. Body weight (P = 0.037) and the levels of fasting blood sugar (P = 0.014), serum total cholesterol (P = 0.017), blood urea nitrogen (P = 0.030), compensated calcium (P < 0.001), inorganic phosphorus (P < 0.001), bone-specific alkaline phosphatase (P < 0.001), and compensated urinary deoxypyridinoline (P < 0.001) increased significantly. Peripheral red blood cell counts (P < 0.001), hemoglobin level (P < 0.001), hematocrit (P < 0.001), uric acid (P < 0.001), and radial bone density (P = 0.023) decreased significantly. These effects of ADT on various bodily functions warrant systematic study in clinical trials. We should be aware of the far-reaching consequences of ADT and incorporate strategies for preventing and managing adverse effects into routine practice.

Publication types

  • Clinical Trial

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Aged, 80 and over
  • Androgen Antagonists / therapeutic use*
  • Blood Glucose / metabolism
  • Blood Urea Nitrogen
  • Body Weight
  • Cholesterol / blood
  • Erythrocyte Count
  • Flutamide / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Orchiectomy
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology


  • Androgen Antagonists
  • Blood Glucose
  • Flutamide
  • Cholesterol