In vivo detection of microglial activation in frontotemporal dementia

Ann Neurol. 2004 Dec;56(6):894-7. doi: 10.1002/ana.20332.


Using positron emission tomography and [(11)C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [(11)C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [(11)C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Chi-Square Distribution
  • Dementia / metabolism*
  • Dementia / pathology
  • Follow-Up Studies
  • Humans
  • Isoquinolines / metabolism
  • Microglia / metabolism*
  • Microglia / pathology
  • Middle Aged
  • Protein Binding


  • Isoquinolines
  • PK 11195