Increasing prevalence of antibiotic resistance and multi drug resistance among uropathogens

J Commun Dis. 2003 Jun;35(2):102-8.

Abstract

A study was conducted to examine the prevalence of antibiotic resistance in the strains of bacteria isolated from patients with suspected urinary tract infection. A total of 348 bacterial isolates were grown from semi quantitative urine culture and were of significant bacteriuria. The antibiotic susceptibility testing was performed on Muller-Hinton agar by disc diffusion method according to the standard criteria of the National Committee for Clinical Laboratory Standards, Antibiotic susceptibility testing revealed a high prevalence of resistance to ampicillin (55.4%) followed by nitrofurantoin (45.4%), gentamicin (45.1%), amikacin (41.4%) and co-trimoxazole (30.5%). E. coli and Klebsiella pneumonia showed 78.8 % and 75.3 % resistance to three or more drugs respectively. Cefotaxime (87.1%) appeared to be the most active antibiotic against the majority of isolates, followed by Norfloxacin (83.3%).

MeSH terms

  • Adolescent
  • Adult
  • Amikacin / pharmacology
  • Amikacin / therapeutic use
  • Ampicillin / pharmacology
  • Ampicillin / therapeutic use
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • Drug Resistance, Multiple*
  • Escherichia coli / drug effects*
  • Female
  • Gentamicins / pharmacology
  • Gentamicins / therapeutic use
  • Humans
  • India / epidemiology
  • Klebsiella pneumoniae / drug effects*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Nitrofurantoin / pharmacology
  • Nitrofurantoin / therapeutic use
  • Prevalence
  • Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Ampicillin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Amikacin
  • Nitrofurantoin