[The tissue-specific methylation of human-specific endogenous retroviral long terminal repeats]

Bioorg Khim. 2004 Sep-Oct;30(5):493-8. doi: 10.1023/b:rubi.0000043787.07628.2a.
[Article in Russian]


A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / genetics
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • DNA Methylation*
  • Deoxyribonuclease HpaII / genetics
  • Deoxyribonuclease HpaII / metabolism
  • Electron Transport Complex I
  • Endogenous Retroviruses / genetics*
  • Gene Expression Regulation
  • Gene Order
  • Humans
  • Liver / physiology
  • Liver / virology
  • Lung / physiology
  • Lung / virology
  • Lymph Nodes / physiology
  • Lymph Nodes / virology
  • NADH Dehydrogenase
  • Organ Specificity
  • Proteins / genetics
  • Terminal Repeat Sequences*


  • NDUFV1 protein, human
  • Proteins
  • NADH Dehydrogenase
  • Deoxyribonuclease HpaII
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Electron Transport Complex I