Abstract
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / genetics
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Cyclic Nucleotide Phosphodiesterases, Type 4
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DNA Methylation*
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Deoxyribonuclease HpaII / genetics
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Deoxyribonuclease HpaII / metabolism
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Electron Transport Complex I
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Endogenous Retroviruses / genetics*
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Gene Expression Regulation
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Gene Order
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Humans
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Liver / physiology
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Liver / virology
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Lung / physiology
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Lung / virology
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Lymph Nodes / physiology
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Lymph Nodes / virology
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NADH Dehydrogenase
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Organ Specificity
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Proteins / genetics
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Terminal Repeat Sequences*
Substances
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NDUFV1 protein, human
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Proteins
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NADH Dehydrogenase
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Deoxyribonuclease HpaII
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Electron Transport Complex I