The purpose of this article was to quantify the exercise load and investigate the influence of physical exercise on adipose tissue in obese women from Bénin. Twelve subjects participated at the study. Six of the subjects trained three times a week for six months. Each training session lasted forty-five minutes. The remaining six women constituted the control group. Biopsy samples of adipose tissue were taken from the same site in the gluteal iliac region at the end of six months and analyzed by histochemistry and electron microscopy. The results showed that all subjects suffered from severe central obesity; lipid content and number of adipocytes were higher among the sedentary woman than among those who exercised. Intense exercise in the latter used more lipids than carbohydrates. We conclude that regular, supervised physical exercise reduces lipid levels and thus induces weight loss.