Effects of egg yolk proteins on the longitudinal bone growth of adolescent male rats

Biosci Biotechnol Biochem. 2004 Nov;68(11):2388-90. doi: 10.1271/bbb.68.2388.


Hen egg is a nutritional store for a new life. We examined the effect of egg yolk proteins on longitudinal bone growth in the rat. Protein fractions from egg yolk were tested. Milk protein, casein, was used as a control. The bone growth rate was significantly increased by yolk water-soluble protein (YSP, 100 mg/kg) administration for 5 d. The bone morphogenetic protein-2 immunostaining of growth plate was also increased. Considering the results, YSP can be used as a growth-promoting factor.

MeSH terms

  • Animals
  • Benzoxazines
  • Bone Development / drug effects*
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / metabolism
  • Bone and Bones / cytology
  • Caseins / pharmacology
  • Chondrocytes / drug effects
  • Egg Proteins / pharmacology*
  • Male
  • Oxazines
  • Rats
  • Rats, Sprague-Dawley
  • Stimulation, Chemical
  • Transforming Growth Factor beta / metabolism


  • Benzoxazines
  • Bmp2 protein, rat
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Caseins
  • Egg Proteins
  • Oxazines
  • Transforming Growth Factor beta
  • cresyl violet