EDTA treatment of intermittent claudication--a double-blind, placebo-controlled study

J Intern Med. 1992 Mar;231(3):261-7. doi: 10.1111/j.1365-2796.1992.tb00533.x.


A double-blind, randomized multicentre study was undertaken to evaluate the possible effect of chelation treatment with ethylenediamine-tetraacetic acid (EDTA) in patients with severe intermittent claudication. A total of 153 patients received 20 intravenous infusions of either 3 g Na2EDTA or placebo during a period of 5-9 weeks. Vitamin, mineral and trace element supplements were administered orally. The changes observed in the pain-free and maximal walking distances, measured on a treadmill, were similar in the two groups. During the 3-month (n = 149) and 6-month (n = 123) follow-up period, no long-term therapeutic effect of EDTA could be demonstrated. The ankle-brachial blood pressure index remained unchanged throughout the study period. This study failed to demonstrate any effect of EDTA chelation treatment in intermittent claudication.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Double-Blind Method
  • Edetic Acid / therapeutic use*
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Humans
  • Infusions, Intravenous
  • Intermittent Claudication / drug therapy*
  • Male
  • Middle Aged
  • Walking


  • Edetic Acid