The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients

J Rheumatol. 1992 Jan;19(1):160-3.


In a cohort of 72 patients with iridocyclitis (iritis) and early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) the course of the eye disease was matched with ocular outcome. Chronicity of inflammation (greater than 6 months/episode) was correlated with complications of eye disease that caused impairment of vision. HLA antigens in these patients were compared with the HLA antigens in a cohort of 77 patients with EOPA-JRA in whom iridocyclitis had failed to develop over a followup of 5 years or longer. HLA-DR5 (11) was correlated with the presence of eye disease, and HLA-DR1 with its absence; HLA-DRw8, which strongly predisposes to EOPA-JRA, was neutral with respect to eye disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Juvenile / complications*
  • Arthritis, Juvenile / genetics
  • Arthritis, Juvenile / immunology
  • Child, Preschool
  • Female
  • Genes
  • HLA-D Antigens / analysis
  • HLA-D Antigens / genetics
  • Humans
  • Immunogenetics
  • Iridocyclitis / etiology*
  • Iridocyclitis / physiopathology
  • Male


  • HLA-D Antigens