Filovirus budding

Virus Res. 2004 Dec;106(2):181-8. doi: 10.1016/j.virusres.2004.08.014.


Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as well as cellular, proteins in the assembly and budding processes has been achieved. This review will discuss the current state of filovirus budding research, with especial emphasis placed on the viral matrix protein VP40 and its relationship with the cellular vesicular sorting pathway. Possible budding functions of the viral glycoprotein (GP), as well as the membrane-associated viral protein 24 (VP24), will also be described, and a model for filovirus budding will be proposed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Filoviridae / chemistry
  • Filoviridae / physiology*
  • Humans
  • Viral Matrix Proteins / analysis
  • Viral Matrix Proteins / physiology*
  • Virion / physiology
  • Virus Assembly / physiology*


  • Viral Matrix Proteins