A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx

Kulak Burun Bogaz Ihtis Derg. 2003 Dec;11(6):183-8.

Abstract

A thirty-seven-year-old male patient presented with dysphagia and hoarseness six months after complete remission of acute myeloid leukemia (AML-M0), which had been treated with chemotherapy. Physical examination revealed left vocal cord paralysis and involvement of the 9th, 10th, and 12th cranial nerves. Sagittal and axial magnetic resonance scans of the nasopharynx and neck showed a mass in the left retropharyngeal and perivertebral regions, 6x4 cm in size; another mass in the left vallecula, and infiltration of the right preepiglottic tissue by another mass of 2 cm. There was no bone marrow involvement. A diagnosis of granulocytic sarcoma without leukemia relapse was made and the FLAG-Ida regimen was administered, after which partial regression of the masses was observed. However, the patient died due to a pulmonary infection on the 17th day of chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Deglutition Disorders / etiology
  • Diagnosis, Differential
  • Fatal Outcome
  • Hoarseness / etiology
  • Humans
  • Laryngeal Neoplasms / complications
  • Laryngeal Neoplasms / diagnosis*
  • Laryngeal Neoplasms / diagnostic imaging
  • Laryngeal Neoplasms / pathology
  • Leukemia, Myeloid, Acute*
  • Magnetic Resonance Imaging
  • Male
  • Nasopharyngeal Neoplasms / complications
  • Nasopharyngeal Neoplasms / diagnosis*
  • Nasopharyngeal Neoplasms / diagnostic imaging
  • Nasopharyngeal Neoplasms / drug therapy
  • Nasopharyngeal Neoplasms / pathology
  • Sarcoma, Myeloid / complications
  • Sarcoma, Myeloid / diagnosis*
  • Sarcoma, Myeloid / diagnostic imaging
  • Sarcoma, Myeloid / drug therapy
  • Sarcoma, Myeloid / pathology
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents