Closing mitosis: the functions of the Cdc14 phosphatase and its regulation

Annu Rev Genet. 2004;38:203-32. doi: 10.1146/annurev.genet.38.072902.093051.


Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding yeast, the protein phosphatase Cdc14 is a key regulator of these late mitotic events. Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology*
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Gene Expression Regulation, Fungal*
  • Mitosis*
  • Models, Biological
  • Phosphorylation
  • Protein Tyrosine Phosphatases / metabolism
  • Protein Tyrosine Phosphatases / physiology*
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomyces cerevisiae Proteins / physiology*
  • Schizosaccharomyces / metabolism
  • Schizosaccharomyces pombe Proteins / metabolism
  • Schizosaccharomyces pombe Proteins / physiology
  • Signal Transduction


  • CDC14 protein, S cerevisiae
  • Cell Cycle Proteins
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Cyclin-Dependent Kinases
  • Protein Tyrosine Phosphatases