Comparative genomic structure of prokaryotes

Annu Rev Genet. 2004;38:771-92. doi: 10.1146/annurev.genet.38.072902.094318.


Recent advances in DNA-sequencing technologies have made available an enormous resource of data for the study of bacterial genomes. The broad sample of complete genomes currently available allows us to look at variation in the gross features and characteristics of genomes while the detail of the sequences reveal some of the mechanisms by which these genomes evolve. This review aims to describe bacterial genome structures according to current knowledge and proposed hypotheses. We also describe examples where mechanisms of genome evolution have acted in the adaptation of bacterial species to particular niches.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Bacteria / genetics*
  • Base Composition
  • Databases, Genetic
  • Evolution, Molecular
  • Gene Order
  • Genes, Bacterial*
  • Genome Components
  • Genome, Bacterial*
  • Species Specificity
  • Synteny