Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease

Int J Dermatol. 2004 Dec;43(12):900-3. doi: 10.1111/j.1365-4632.2004.02020.x.

Abstract

Background: Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD.

Methods: In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects.

Results: Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant.

Conclusions: The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Alleles
  • Apolipoproteins E / genetics*
  • Behcet Syndrome / blood*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cholesterol, VLDL / blood
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Lipoproteins / blood*
  • Male
  • Polymorphism, Genetic / genetics*
  • Triglycerides / blood

Substances

  • Apolipoproteins E
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Lipoproteins
  • Triglycerides
  • Cholesterol