Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 87 (3), 187-9

A Novel B(var) Allele (547 G>A) Demonstrates Differential Expression Depending on the Co-Inherited ABO Allele

Affiliations

A Novel B(var) Allele (547 G>A) Demonstrates Differential Expression Depending on the Co-Inherited ABO Allele

D Cho et al. Vox Sang.

Abstract

Background and objectives: Genetic analysis of group B donors in Korea was performed.

Materials and methods: Exons 6 and 7 were sequenced in 12 phenotypically B3 donors 6 B3, 6 A1B3.

Results: Consensus sequences all B3 and 2/6 A1B3 donors were present. Four A1B3 donors demonstrated a novel B allele, B(var), in the context of A101/ or A102/B(var) genotypes. Family studies based on an A1B3 donor with the B(var) allele and on another unrelated subject with identical genotype and phenotype revealed B(var)/O01 genotypes with full B-antigen expression.

Conclusions: B(var) allele is subject to differential expression, depending on the co-inherited ABO allele.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

Publication types

LinkOut - more resources

Feedback